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B.C.-based clinical trial of COVID-19 antibody 91Ƶvery promising,91Ƶ says expert

Participation criteria expanded for infusion clinic based at Peace Arch Hospital
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Dr. Gregory Haljan is leading a clinical trial of a COVID-19 antibody. (Contributed photo)

The clinical trial of a drug that one expert says looks 91Ƶvery promising91Ƶ for use in stopping the progression of COVID-19 moved into a new phase this week, with the opportunity to participate now open to all eligible patients in the Fraser Health region.

Dr. Gregory Haljan 91Ƶ head of Surrey Memorial Hospital91Ƶs critical care unit and Fraser Health91Ƶs regional medical director for research 91Ƶ said Monday (April 26) that around 300 COVID-19-positive patients are sought to receive the medication bamlanivimab as part of the B-EPIC (Bamlanivimab-Emergency Passive Immunity in COVID-19) study.

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Designed in January, the study aims to determine if the antibody can prevent those who get COVID-19 from getting so sick they need to be hospitalized 91Ƶ and if it can, 91Ƶwell, we really need that right now,91Ƶ Haljan said.

91ƵWe91Ƶre in the third wave,91Ƶ Haljan said of the pandemic. 91ƵThis is the worst it91Ƶs been (in the SMH intensive care unit) yet. We91Ƶre working about as hard as we can right now in the ICU.

91ƵThis third wave has been a real kick in the pants.91Ƶ

Researchers also want to learn if bamlanivimab can reduce the long-term effects of the illness.

Its use for COVID-19 treatment in high-risk patients has interim approval from Health Canada. The drug is designed to block the COVID-19 virus from attaching to and entering cells, thus potentially preventing the illness from worsening in newly diagnosed patients.

91ƵOnce you get an infection, it91Ƶs too late for a vaccine to work,91Ƶ Haljan said. 91ƵWhat we want to do is provide those antibodies (that a vaccine typically triggers a body to produce) early in the disease, to give the immune system a head start.91Ƶ

Recruiting for the study opened in March to residents of Surrey, White Rock and Delta. It then expanded to include patients living in Burnaby, Langley, Maple Ridge and Pitt Meadows.

Haljan said participants must begin the therapy within three days of a positive COVID-19 test, or within 10 days of their first symptoms.

Eligible participants are those 65 and older, or between 18 and 64 years old who have tested positive for COVID-19 and have at least one illness or condition that puts them at risk of being hospitalized for COVID-19 infection.

Haljan hopes to recruit up to 20 patients per day over the next two weeks, in order to complete the study by May 9.

Currently, the medication is being delivered at an infusion clinic set up at Peace Arch Hospital, but Haljan said the hope is to establish more clinics this week, particularly in the Fraser East area.

He emphasized that while the medication only has interim approval, it is 91Ƶvery safe,91Ƶ and, it has been found to 91Ƶretain activity91Ƶ against the U.K variant of COVID-19; the most prevalent variant in Canada.

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The study, he noted, 91Ƶis asking questions nobody else in the world is asking right now about this drug.91Ƶ

To sign up or for more information, visit



tholmes@peacearchnews.com
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Tracy Holmes

About the Author: Tracy Holmes

Tracy Holmes has been a reporter with Peace Arch News since 1997.
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