A team of UBC Okanagan researchers have found that gut bacteria are linked to the onset of Type 1 diabetes.
Their findings also show that long-term and over-use of antibiotics can accelerate the process by disrupting the gut bacteria.
91裸聊视频淭he incidence of Type 1 diabetes has doubled in the last few years in Western countries, and this is most obvious in children aged 1 to 5,91裸聊视频� said UBCO assistant professor Deanna Gibson, the study91裸聊视频檚 senior author.
91裸聊视频淭his suggests that early life events are critical to health. Our research pinpoints the significant role of bacteria and how antibiotic use can alter their normal development in the gut which then can alter the health of these individuals.91裸聊视频�
91裸聊视频淲hile it91裸聊视频檚 clear that antibiotics are very useful in medicine, overusing them can have significant consequences.91裸聊视频�
The study, which looked at diabetes-onset in mice, demonstrated that those susceptible to diabetes had more harmful and less beneficial bacteria than those resistant to the disease. The researchers also demonstrated that the harmful bacteria generated an immune response, which in turn, stimulated destruction of insulin-producing cells.
91裸聊视频淲e were able to establish a clear relationship between bacteria, the body91裸聊视频檚 immune reaction and the development of Type 1 diabetes,91裸聊视频� added Gibson, a microbiologist at the Irving K. Barber School of Arts and Sciences.
91裸聊视频淭his is likely to have significant implications for treatment of the disease. The next steps are to narrow-in and identify which bacteria induce or perhaps protect against Type 1 diabetes. This, in turn, could help with the production of more specific antibiotics.91裸聊视频�
There are more than 10 million Canadians living with diabetes or prediabetes, a chronic disease in which the body cannot produce or properly use insulin. (Insulin controls the amount of sugar in the blood.) Type 1 diabetes results when the immune system accidently attacks and kills insulin-producing cells.
The research, recently published in the Nature Group91裸聊视频檚 ISME Journal, was supported by the Child and Family Research Institute Diabetes Catalyst Grant from the Canuck91裸聊视频檚 Foundation, the Canadian Institutes of Health Research, the Juvenile Diabetes Research Foundation and the Natural Sciences and Engineering Research Council.
