The National Institutes of Health is beginning a handful of studies to test possible treatments for long COVID, an anxiously awaited step in U.S. efforts against the mysterious condition that afflicts millions.
Monday91裸聊视频檚 announcement from the NIH91裸聊视频檚 $1.15 billion comes amid frustration from patients who91裸聊视频檝e struggled for months or even years with sometimes-disabling health problems 91裸聊视频� with no proven treatments and only a smattering of rigorous studies to test potential ones.
91裸聊视频淭his is a year or two late and smaller in scope than one would hope but nevertheless it91裸聊视频檚 a step in the right direction,91裸聊视频� said Dr. Ziyad Al-Aly of Washington University in St. Louis, who isn91裸聊视频檛 involved with NIH91裸聊视频檚 project but whose own research . Getting answers is critical, he added, because 91裸聊视频渢here91裸聊视频檚 a lot of people out there exploiting patients91裸聊视频� vulnerability91裸聊视频� with unproven therapies.
Scientists don91裸聊视频檛 yet know what causes long COVID, the catchall term for about 200 widely varying symptoms. Between 10% and 30% of people are estimated to have experienced some form of long COVID after recovering from a coronavirus infection, a risk that has dropped somewhat since early in the pandemic.
91裸聊视频淚f I get 10 people, I get 10 answers of what long COVID really is,91裸聊视频� U.S. Health and Human Services Secretary Xavier Becerra said.
That91裸聊视频檚 why so far the RECOVER initiative has tracked 24,000 patients in observational studies to help define the most common and burdensome symptoms 91裸聊视频� findings that now are shaping multipronged treatment trials. The first two will look at:
91裸聊视频� Whether taking up to 25 days of Pfizer91裸聊视频檚 antiviral drug Paxlovid could ease long COVID, because of a theory that some live coronavirus, or its remnants, may hide in the body and trigger the disorder. Normally Paxlovid is used when people first get COVID-19 and for just five days.
91裸聊视频� Treatments for 91裸聊视频渂rain fog91裸聊视频� and other cognitive problems. They include Posit Science Corp.91裸聊视频檚 BrainHQ cognitive training program, another called PASC-Cognitive Recovery by New York City91裸聊视频檚 Mount Sinai Health System, and a Soterix Medical device that electrically stimulates brain circuits.
Two additional studies will open in the coming months. One will test treatments for sleep problems. The other will target problems with the autonomic nervous system 91裸聊视频� which controls unconscious functions like breathing and heartbeat 91裸聊视频� including the disorder called POTS.
A more controversial study of exercise intolerance and fatigue also is planned, with NIH seeking input from some patient groups worried that exercise may do more harm than good for certain long COVID sufferers.
The trials are enrolling 300 to 900 adult participants for now but have the potential to grow. Unlike typical experiments that test one treatment at a time, these more flexible 91裸聊视频減latform studies91裸聊视频� will let NIH add additional potential therapies on a rolling basis.
91裸聊视频淲e can rapidly pivot,91裸聊视频� Dr. Amy Patterson with the NIH explained. A failing treatment can be dropped without ending the entire trial and 91裸聊视频渋f something promising comes on the horizon, we can plug it in.91裸聊视频�
The flexibility could be key, according to Dr. Anthony Komaroff, a Harvard researcher who isn91裸聊视频檛 involved with the NIH program but has long studied a similarly mysterious disorder known as chronic fatigue syndrome or ME/CFS. For example, he said, the Paxlovid study 91裸聊视频渕akes all sorts of sense,91裸聊视频� but if a 25-day dose shows only hints of working, researchers could extend the test to a longer course instead of starting from scratch.
Komaroff also said that he understands people91裸聊视频檚 frustration over the wait for these treatment trials, but believes NIH appropriately waited 91裸聊视频渦ntil some clues came in about the underlying biology,91裸聊视频� adding: 91裸聊视频淵ou91裸聊视频檝e got to have targets.91裸聊视频�
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